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Project Description

MOST (Metabolic Optimization and Simulation Tool) is a computational tool for optimizing and simulating genome-scale metabolic models. A primary application of MOST is for in silico design for metabolic engineering.

Simulation: MOST takes models of cellular systems defined by SBML and allows simulation of those systems under varying environmental conditions. It does so using the method of flux-balance analysis.

Optimization: MOST can find sets of gene knockouts that lead to overproduction of particular metabolites. MOST uses a local search heuristic for finding such sets.

Last edited Jul 13, 2010 at 3:15 AM by tkroeger, version 3